A late Brandao goal gave Olympique Marseille a 2-1 win at Lorient which sent them two points clear at the top of Ligue 1 on Sunday.
Olympique Lyon's dip in form is proving to be of concern to the players before next week's Champions League tie against PSV Eindhoven.
Nantes knocked Gerard Houllier's side out on penalties in the second round of the French League Cup.
Inter Milan went 10 points clear in Serie A, while French champions Olympique Lyon were knocked off the top of the Ligue 1 table by Olympique Marseille.
Olympique Lyon needed a late long-range Juninho free kick to beat second division Sedan 1-0 on Wednesday and advance to the French Cup final.
Olympique Lyon coach Claude Puel is under no illusions that his side face a monumental task to reclaim a Ligue 1 title they owned for seven successive seasons without their two most influential players.
Bayern Munich's talismanic playmaker Franck Ribery is fit to start in the Champions League semi-final against Olympique Lyon on Wednesday after skipping training because of muscular problems.
Big-spending Real Madrid failed to qualify for the Champions League quarter-finals for the sixth straight season when Olympique Lyon dumped the Spaniards out 2-1 on aggregate on Wednesday.
Olympique Lyon failed to capitalise on a Lisandro Lopez hat-trick and missed a chance to narrow the gap with Ligue 1 leaders Girondins Bordeaux when they slumped to a dramatic 4-3 defeat at Lille on Sunday.
Olympique Lyon virtually guaranteed their place in the Champions League group stage for the 10th successive season after thumping Anderlecht 5-1 in the first leg of their playoff final on Wednesday.
Olympique Lyon are suing soccer's world governing body over an injury sustained by defender Eric Abidal in a friendly international.
They have 49 points from a maximum 54 after 18 games, with Lens still on 32 points.
Last week's Champions League first leg quarter-final in Lyon ended goalless, leaving Milan needing a victory as a scoring draw would send the French side through on the 'away goals' rule.
The former Brazil international pulled a groin muscle in Sunday's 2-1 home defeat by PAOK Salonika.
Olympique Lyon recovered from going 2-1 down and the dismissal of Fabio Grosso to draw 2-2 at home to Caen on Saturday to edge closer to a seventh successive Ligue 1 title.
Olympique Lyon midfielder Jeremy Toulalan and striker Milan Baros have been left out of the squad to face VfB Stuttgart in a Champions League Group E match on Wednesday.
Liverpool will be without striker Fernando Torres for Tuesday's Champions League clash with Olympique Lyon at Anfield but midfielder Steven Gerrard is expected to be fit, manager Rafael Benitez said on Monday.
Barcelona believe they can quickly regain their momentum after two indifferent league performances when they face Olympique Lyon in their Champions League last 16 first-leg clash at the Stade Gerland on Tuesday. Primera Liga leaders Barca lost 2-1 against Espanyol on Saturday, only their second defeat of the campaign. This followed a draw last week with Real Betis.
Marouane Chamakh struck late to give Ligue 1 leaders Girondins Bordeaux a 1-0 win at Olympique Lyon on Sunday that put their title rivals eight points behind.
Holders Manchester United soothed a painful old wound for Alex Ferguson by knocking Inter Milan out of the Champions League on Wednesday, as Barcelona mauled Olympique Lyon 5-2 in a thrilling return to form. Arsenal made it four English teams in the quarter-finals for the second successive year, their youngsters showing great composure to see them home 7-6 on penalties away to AS Roma.
New signing Yoann Gourcuff made an unhappy debut when Olympique Lyon slumped to a 2-0 defeat at Lorient in Ligue 1 on Saturday.
Paris St Germain's league record 36-game unbeaten streak came to an abrupt halt when they lost 2-1 at Olympique Lyonnais on Sunday.
A round-up of Saturday's action the Bundesliga, Ligue 1
Liverpool's Champions League winning trio of Mohamed Salah, Virgil van Dijk and Sadio Mane joined regulars Cristiano Ronaldo and Lionel Messi on the shortlist for The Best FIFA Men's player award
Manchester City reached the Champions League quarter-finals after beating Real Madrid 2-1 (4-2 on aggregate) at the Etihad Stadium on Friday, with scorers Raheem Sterling and Gabriel Jesus taking advantage of errors by defender Raphael Varane.
Substitute Moussa Dembele scored twice as Olympique Lyonnais stunned Manchester City on Saturday to move into the semi-finals of the UEFA Champions League.
Paris St Germain continued their irrepressible march towards a fourth consecutive Ligue 1 title with a 5-1 home win against Olympique Lyonnais to move 17 points clear at the top.
Inter Milan grabbed a slender advantage over Villarreal with a 2-1 comeback win the in Champions League first-leg quarter-final
Manager Rafael Benitez confirmed Liverpool are weighing up bids from Aston Villa and Olympique Lyon for Milan Baros.
A summary of results from matches played in the Italian Serie A and Ligue 1
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